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Kari Sant

Kari Sant , PhD

she/her/hers
Associate Professor
Pharmacology & Toxicology

Education

Doctor of Philosophy, Environmental Health Sciences, University of Michigan, 2010
Master of Public Health, Environmental Health Sciences, University of Michigan, 2008
Bachelor of Science, Biology, Program in the Environment, University of Michigan, 2003

Employment

Associate Professor, Michigan State University, East Lansing, 2024 - Present
Associate Professor of Environmental Health, San Diego State University, San Diego, 2022 - 2024
Assistant Professor of Environmental Health, San Diego State University, San Diego, 2018 - 2022
Postdoctoral Research Fellow, University of Massachusetts Amherst, Amherst, 2015 - 2018

Publications

Targeted and nontargeted approaches to uncover complex halogenated pollutants in the historically endangered California brown pelican Environmental Pollution (2025)

Integrating network analysis and machine learning to elucidate chemical-induced pancreatic toxicity in zebrafish embryos Toxicological Sciences (2025)

Housing and Lead in Detroit: A Historic Perspective Environmental Justice (2025)

Effects of sunlight exposure on tire tread particle leachates: Chemical composition and toxicity in aquatic systems Environmental Pollution (2025)

Behavior of compounds leached from tire tread particles under simulated sunlight exposure Water Research (2025)

Reproductive toxicity of DDT in the Japanese medaka fish model: Revisiting the impacts of DDT+ on female reproductive health Chemosphere (2024)

Novel chemical contaminants associated with thirdhand smoke in settled house dust Chemosphere (2024)

Metagenomic analysis of microbial communities and antibiotic resistant genes in the Tijuana river, and potential sources Environmental Pollution (2024)

Development of a Dynamic Network Model to Identify Temporal Patterns of Structural Malformations in Zebrafish Embryos Exposed to a Model Toxicant, Tris(4-chlorophenyl)methanol Journal of Xenobiotics (2023)

The Influence of Cannabinoids on Drosophila Behaviors, Longevity, and Traumatic Injury Responses of the Adult Nervous System. Cannabis and cannabinoid research (2023)

Tris(4‐chlorophenyl)methane and tris(4‐chlorophenyl)methanol disrupt pancreatic organogenesis and gene expression in zebrafish embryos Birth Defects Research (2023)

Metagenomic Analysis of Microbial Contamination in the U.S. Portion of the Tijuana River Watershed International Journal of Environmental Research and Public Health (2022)

Detection, Quantification, and Simplified Wastewater Surveillance Model of SARS-CoV-2 RNA in the Tijuana River ACS ES&T Water (2022)

Association between particulate matter air pollution and heart attacks in San Diego County Journal of the Air & Waste Management Association (2021)

Associations between Exposures to Perfluoroalkyl Substances and Diabetes, Hyperglycemia, or Insulin Resistance: A Scoping Review Journal of Xenobiotics (2021)

The Role of Diversity, Equity, and Inclusion in the Future of Toxicology Toxicological Sciences (2021)

Modulation of PPAR signaling disrupts pancreas development in the zebrafish, Danio rerio. Toxicology and applied pharmacology (2021)

Mathematical modeling of the interaction between yolk utilization and fish growth in zebrafish, Danio rerio Development (2021)

Developmental exposures to perfluorooctanesulfonic acid (PFOS) impact embryonic nutrition, pancreatic morphology, and adiposity in the zebrafish, Danio rerio Environmental Pollution (2021)

Maternal preconception PFOS exposure of Drosophila melanogaster alters reproductive capacity, development, morphology and nutrient regulation. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association (2021)

The ecotoxicological contaminant tris(4-chlorophenyl)methanol (TCPMOH) impacts embryonic development in zebrafish (Danio rerio). Aquatic toxicology (Amsterdam, Netherlands) (2021)

Embryonic exposures to mono-2-ethylhexyl phthalate induce larval steatosis in zebrafish independent of Nrf2a signaling Journal of Developmental Origins of Health and Disease (2021)

The emerging contaminant 3,3'-dichlorobiphenyl (PCB-11) impedes Ahr activation and Cyp1a activity to modify embryotoxicity of Ahr ligands in the zebrafish embryo model (Danio rerio). Environmental pollution (Barking, Essex : 1987) (2019)

The emerging contaminant 3,3″-dichlorobiphenyl (PCB-11) impedes Ahr activation and Cyp1a activity to modify embryotoxicity of Ahr ligands in the zebrafish embryo model (Danio rerio) Environmental Pollution (2019)

Perfluorobutanesulfonic Acid Disrupts Pancreatic Organogenesis and Regulation of Lipid Metabolism in the Zebrafish, Danio rerio Toxicological Sciences (2019)

Embryonic exposure to Mono(2-ethylhexyl) phthalate (MEHP) disrupts pancreatic organogenesis in zebrafish (Danio rerio) Chemosphere (2018)

Zebrafish as a Model for Toxicological Perturbation of Yolk and Nutrition in the Early Embryo Current Environmental Health Reports (2018)

Nrf2a Modulates the Embryonic Antioxidant Response to Perfluorooctanesulfonic Acid (PFOS) in the Zebrafish, Danio rerio Aquatic Toxicology (2018)

Nrf2a modulates the embryonic antioxidant response to perfluorooctanesulfonic acid (PFOS) in the zebrafish, Danio rerio Aquatic Toxicology (2018)

Fumonisin, Folate and other Methyl Donors and Neural Tube Defects Comprehensive Toxicology: Third Edition (2018)

Methods for analysis of DNA methylation Toxicoepigenetics: Core Principles and Applications (2018)

Pancreatic beta cells are a sensitive target of embryonic exposure to butylparaben in zebrafish (Danio rerio) Birth Defects Research (2018)

The role of Nrf1 and Nrf2 in the regulation of glutathione and redox dynamics in the developing zebrafish embryo. Redox biology (2017)

Novel Epigenetic Biomarkers Mediating Bisphenol A Exposure and Metabolic Phenotypes in Female Mice Endocrinology (2016)

Embryonic exposures to perfluorooctanesulfonic acid (PFOS) disrupt pancreatic organogenesis in the zebrafish, Danio rerio Environmental Pollution (2016)

Assessment of Toxicological Perturbations and Variants of Pancreatic Islet Development in the Zebrafish Model Toxics (2016)

Epigenome-wide DNA methylation analysis implicates neuronal and inflammatory signaling pathways in adult murine hepatic tumorigenesis following perinatal exposure to bisphenol A. (2016)

Mono-2-ethylhexyl phthalate disrupts neurulation and modifies the embryonic redox environment and gene expression Reproductive Toxicology (2016)

Deviant development of pancreatic beta cells from embryonic exposure to PCB-126 in zebrafish Comparative Biochemistry and Physiology Part C: Toxicology & Pharmacology (2015)

Mono-2-ethylhexyl phthalate (MEHP) alters histiotrophic nutrition pathways and epigenetic processes in the developing conceptus. (2015)

Regulation of Ahr signaling by Nrf2 during development: Effects of Nrf2a deficiency on PCB126 embryotoxicity in zebrafish (Danio rerio) Aquatic Toxicology (2015)

Amino Acid Starvation Induced by Protease Inhibition Produces Differential Alterations in Redox Status and the Thiol Proteome in Organogenesis-Stage Rat Embryos and Visceral Yolk Sacs Journal of Nutritional Biochemistry (2015)

Ethanol Attenuates Histiotrophic Nutrition Pathways and Alters the Intracellular Redox Environment and Thiol Proteome during Rat Organogenesis. (2015)

Inhibition of glutathione biosynthesis alters compartmental redox status and the thiol proteome in organogenesis-stage rat conceptuses. (2013)

Inhibition of proteolysis in histiotrophic nutrition pathways alters DNA methylation and one-carbon metabolism in the organogenesis-stage rat conceptus. (2013)

Nutrition and epigenetics: an interplay of dietary methyl donors, one-carbon metabolism and DNA methylation. (2012)

DNA methylation screening and analysis. (2012)

Fundings

Assessing Fate and Toxicity of Microplastics under Coastal Environment Conditions

Global Centers: International Research Center for Enhancing Plant Resilience

Integrating Computational and Experimental Models to Predict Toxicity of the Pancreas

Interactions between PPAR, embryonic nutrition, and the developmental origins of metabolic dysfunction

Elucidating the role of PPAR signaling in pancreatic organogenesis and juvenile metabolic syndrome

Toxicant disruption of receptor-mediated endocytosis in oogenesis and later life metabolic dysfunction

Sunlight and tire wear particles - a toxic combination? Evaluating mechanisms for mobilization and degradation of tire particle compounds

RP-Sant/Quintana: Assessment of Exposure to Microbial and Chemical Pollution in US Community Air from the Binational Tijuana River Watershed

Hazard assessment of deep ocean DDT disposal: Defining biomagnified DDT+ chemical profiles and investigating the health impacts on sentinel wildlife species and humans

Environmental Toxicity of Electronic Cigarette and Heated Tobacco Product Components and Waste

Surface Water Emissions from Cannabis Cultivation Sites: Quantity, Quality, Toxicity, and Relationships to Farmers' Practices