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Cheryl Rockwell

Cheryl Rockwell , PhD

she/her/hers
Associate Professor
Pharmacology & Toxicology
214 Food Safety & Toxicology

Employment

Associate Professor, Michigan State University, East Lansing, 2017 - Present
Assistant Professor, Michigan State University, East Lansing, 2011 - 2017

Publications

Angiotensin II Infusion Promotes Activation and Selective Cytokine Responses in Activated CD4 and CD8 T cells (2025)

Sex differences in cytokine induction by activated T cells from hypertensive BPH/2 and normotensive BPN/3 mice (2025)

A high-fat hypertensive diet induces a coordinated perturbation signature across cell types in thoracic perivascular adipose tissue (2025)

A cell atlas of thoracic aortic perivascular adipose tissue: a focus on mechanotransducers American Journal of Physiology-Heart and Circulatory Physiology (2024)

Trivalent arsenic impairs the effector response of human CD4+ and CD8+ T cells to influenza A virus ex vivo Food and Chemical Toxicology (2022)

Chronic low-level cadmium exposure in rats affects cytokine production by activated T cells Toxicology Research (2019)

Differential Sensitivity of Kupffer Cells and Hepatic Monocyte-Derived Macrophages to Bacterial Lipopolysaccharide Clin Exp Gastroenterol Hepatol (2019)

Comparison of Hepatic NRF2 and Aryl Hydrocarbon Receptor Binding in 2,3,7,8-Tetrachlorodibenzo-p-dioxin-Treated Mice Demonstrates NRF2-Independent PKM2 Induction Mol Pharmacol (2018)

Differential effects of the Nrf2 activators tBHQ and CDDO-Im on the early events of T cell activation Biochem Pharmacol (2018)

Identification of an Unfavorable Immune Signature in Advanced Lung Tumors from Nrf2-Deficient Mice Antioxid Redox Signal (2018)

The Nrf2 activator tBHQ inhibits the activation of primary murine natural killer cells Food Chem Toxicol (2018)

Inhibition of early T cell cytokine production by arsenic trioxide occurs independently of Nrf2 PLoS One (2017)

Nrf2-Dependent and -Independent Effects of tert-Butylhydroquinone, CDDO- Im, and H2O2 in Human Jurkat T Cells as Determined by CRISPR/Cas9 Gene Editing J Pharmacol Exp Ther (2017)

Persistent alterations in immune cell populations and function from a single dose of perfluorononanoic acid (PFNA) in C57Bl/6 mice Food Chem Toxicol (2017)

Pharmacological Inhibition of Myocardin-related Transcription Factor Pathway Blocks Lung Metastases of RhoC-Overexpressing Melanoma Mol Cancer Ther (2017)

Fibrin deposition following bile duct injury limits fibrosis through an alphaMbeta2-dependent mechanism Blood (2016)

Individual bile acids have differential effects on bile acid signaling in mice Toxicol Appl Pharmacol (2015)

The Nrf2 activator tBHQ inhibits T cell activation of primary human CD4 T cells Cytokine (2015)

Enhanced allergic airway disease in old mice is associated with a Th17 response Clin Exp Allergy (2014)

Fas-induced apoptosis increases hepatocyte tissue factor procoagulant activity in vitro and in vivo Toxicol Sci (2014)

Hepatic stellate cells orchestrate clearance of necrotic cells in a hypoxia-inducible factor-1alpha-dependent manner by modulating macrophage phenotype in mice J Immunol (2014)

Acute Immunotoxic Effects of Perfluorononanoic Acid (PFNA) in C57BL/6 Mice Clin Exp Pharmacol (2013)

Hepatocyte tissue factor activates the coagulation cascade in mice Blood (2013)

IL-17A synergistically enhances bile acid-induced inflammation during obstructive cholestasis Am J Pathol (2013)

The Nrf2 activator, tBHQ, differentially affects early events following stimulation of Jurkat cells Toxicol Sci (2013)

A critical role for the inducible proteasomal subunits LMP7 and MECL1 in cytokine production by activated murine splenocytes Pharmacology (2012)

Effect of bile duct ligation on bile acid composition in mouse serum and liver Liver Int (2012)

Th2 skewing by activation of Nrf2 in CD4(+) T cells J Immunol (2012)

Protease-activated receptor 1 and hematopoietic cell tissue factor are required for hepatic steatosis in mice fed a Western diet Am J Pathol (2011)

ChIPing the cistrome of PXR in mouse liver Nucleic Acids Res (2010)

Differential effects of lactacystin on cytokine production in activated Jurkat cells and murine splenocytes Cytokine (2010)

Lipid A-mediated tolerance and cancer therapy Adv Exp Med Biol (2010)

Transcriptional regulation of renal cytoprotective genes by Nrf2 and its potential use as a therapeutic target to mitigate cisplatin-induced nephrotoxicity J Pharmacol Exp Ther (2010)

A COX-2 metabolite of the endogenous cannabinoid, 2-arachidonyl glycerol, mediates suppression of IL-2 secretion in activated Jurkat T cells Biochem Pharmacol (2008)

A combination of proteasome inhibitors and antibiotics prevents lethality in a septic shock model Innate Immun (2008)

Interleukin-2 suppression by 2-arachidonyl glycerol is mediated through peroxisome proliferator-activated receptor gamma independently of cannabinoid receptors 1 and 2 Mol Pharmacol (2006)

2-Arachidonoyl-glycerol suppresses interferon-gamma production in phorbol ester/ionomycin-activated mouse splenocytes independent of CB1 or CB2 J Leukoc Biol (2005)

A cyclooxygenase metabolite of anandamide causes inhibition of interleukin-2 secretion in murine splenocytes J Pharmacol Exp Ther (2004)

Evidence for cannabinoid receptor-dependent and -independent mechanisms of action in leukocytes J Pharmacol Exp Ther (2003)

In the News

Immune System Remains an Unending Source of Fascination for Dr. Cheryl Rockwell

Mysterious, complicated, and misunderstood, the body's immune remains a source of fascination for Dr. Cheryl Rockwell. "I need to find things not to work sometimes,” she said. “Because that brings the new questions, and that’s what makes it interesting."