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Kyle Poulsen

Kyle Poulsen , PhD

Assistant Professor

Employment

Assistant Professor, Michigan State University, East Lansing, 2025 - Present
Assistant Professor, Texas Medical Center, Houston, 2020 - 2024

Publications

RIP3 and MLKL regulate ER stress in alcohol-associated liver disease and pharmacological ER stress models: Insights beyond necroptosis JHEP Reports (2026)

Updates on the Immune Cell Basis of Hepatic Ischemia-Reperfusion Injury Molecules and Cells (2023)

Hepatic recruitment of eosinophils and their protective function during acute liver injury Journal of Hepatology (2022)

Radiofrequency ablation remodels the tumor microenvironment and promotes systemic immunomodulation in pancreatic cancer (2022)

Role of MIF in coordinated expression of hepatic chemokines in patients with alcohol-associated hepatitis JCI Insight (2021)

Inhibition of IRAK4 kinase activity improves ethanol-induced liver injury in mice Journal of Hepatology (2020)

MLKL-dependent signaling regulates autophagic flux in a murine model of non-alcoholic fatty liver disease Journal of Hepatology (2020)

Novel Role of Macrophage Migration Inhibitory Factor in Upstream Control of the Unfolded Protein Response After Ethanol Feeding in Mice Alcoholism: Clinical and Experimental Research (2019)

The non-transcriptional activity of IRF3 modulates hepatic immune cell populations in acute-on-chronic ethanol administration in mice Journal of Hepatology (2019)

Anaphylatoxin receptors C3aR and C5aR1 are important factors that influence the impact of ethanol on the adipose secretome Frontiers in Immunology (2018)

Complement factor d protects mice from ethanol-induced inflammation and liver injury American Journal of Physiology - Gastrointestinal and Liver Physiology (2018)

Hepatic Immune System: Adaptations to Alcohol Handbook of Experimental Pharmacology (2018)

Hepatocyte-derived macrophage migration inhibitory factor mediates alcohol-induced liver injury in mice and patients Journal of Hepatology (2017)

Trovafloxacin-induced replication stress sensitizes HepG2 cells to tumor necrosis factor-alpha-induced cytotoxicity mediated by extracellular signal-regulated kinase and ataxia telangiectasia and Rad3-related Toxicology (2015)

Trovafloxacin enhances lipopolysaccharide-stimulated production of tumor necrosis factor-α by macrophages: Role of the DNA damage responses Journal of Pharmacology and Experimental Therapeutics (2014)

Trovafloxacin potentiation of Lipopolysaccharide-Induced Tumor necrosis factor release from RAW 264.7 Cells requires extracellular signal-regulated kinase and c-Jun N-Terminal kinases Journal of Pharmacology and Experimental Therapeutics (2014)

In the News

After "Interesting" Journey, Dr. Kyle Poulsen is doing the research he loves in the place he loves doing it

He has spent years studying the impact of alcohol on the liver and how to help those in need. Now at MSU, he is hopeful to take that research in new directions. “We’re trying to make new therapies, and that’s the other arm of pharmacology and toxicology," he said.