James Luyendyk , PhD

Publications

Age-associated increases in PAI-1 silenced with siRNA-lipid nanoparticles reduces thrombosis and prolongs lifespan Blood (2026)

Fibrin and Fibrinolysis in Liver, Kidney, and Lung Transplantation Arterioscler Thromb Vasc Biol (2026)

Role of the Plasminogen Activation System in Liver Injury and Repair: Knowns and Known Unknowns Arterioscler Thromb Vasc Biol (2026)

Tissue transglutaminase drives fibrin β-chain cross-linking: a novel fibrin modification observed in patients with trauma Blood (2026)

Urokinase Plasminogen Activator Deficiency Delays the Development of Obesity and Metabolic Sequelae Arterioscler Thromb Vasc Biol (2026)

Factor XIII: driving (cross-)links in hemostasis, thrombosis, and disease Blood (2025)

Integrated cross-linking by TG2 and FXIII generates hepatoprotective fibrin(ogen) deposits in injured liver Blood (2025)

Kupffer cell expression of macrophage receptor with collagenous structure modulates macrophage gene induction and limits acute liver injury Toxicol Sci (2025)

Platelets mediate neutrophil infiltration and exacerbate liver injury and sinusoidal endothelial cell damage after a severe acetaminophen overdose in mice Arch Toxicol (2025)

A bovine model of hypoxia-induced pulmonary hypertension reveals a gradient of immune and matrisome response with a complement signature found in circulation Am J Physiol Cell Physiol (2024)

Coagulation factor XIII is a critical driver of liver regeneration after partial hepatectomy J Thromb Haemost (2024)

Fibrinolysis-Mediated Pathways in Acute Liver Injury Semin Thromb Hemost (2024)

Good Cells Go Bad: Immune Dysregulation in the Transition from Acute Liver Injury to Liver Failure After Acetaminophen Overdose Drug Metab Dispos (2024)

Hepatocyte-independent PAR1-biased signaling controls liver pathology in experimental obesity J Thromb Haemost (2024)

Neutrophil-dependent hepatic platelet accumulation and liver injury revealed by acetaminophen dose-response studies Res Pract Thromb Haemost (2024)

Plasminogen deficiency suppresses pancreatic ductal adenocarcinoma disease progression Mol Oncol (2024)

Reciprocal stabilization of coagulation factor XIII-A and -B subunits is a determinant of plasma FXIII concentration Blood (2024)

Altered fibrinogen γ-chain cross-linking in mutant fibrinogen-γ(Δ5) mice drives acute liver injury J Thromb Haemost (2023)

Anticoagulation to prevent disease progression in patients with cirrhosis J Hepatol (2023)

Efficient megakaryopoiesis and platelet production require phospholipid remodeling and PUFA uptake through CD36 Nat Cardiovasc Res (2023)

Interleukin-10 disrupts liver repair in acetaminophen-induced acute liver failure Front Immunol (2023)

Novel genetic regulators of fibrinogen synthesis identified by an in vitro experimental platform J Thromb Haemost (2023)

Robust coagulation activation and coagulopathy in mice with experimental acetaminophen-induced liver failure J Thromb Haemost (2023)

The ISTH SSC Subcommittee on Hemostatic Management of Patients with Liver Disease: goals, ambitions, and call for collaboration J Thromb Haemost (2023)

The ISTH SSC subcommittee on Hemostatic Management of Patients with Liver Disease: goals, ambitions, and call for collaboration: reply J Thromb Haemost (2023)

Turning clots into stardust: nanoparticles stay on target J Thromb Haemost (2023)

Baat Gene Knockout Alters Post-Natal Development, the Gut Microbiome, and Reveals Unusual Bile Acids in Mice J Lipid Res (2022)

Comparison of DLin-MC3-DMA and ALC-0315 for siRNA Delivery to Hepatocytes and Hepatic Stellate Cells Mol Pharm (2022)

Cross-linking by tissue transglutaminase-2 alters fibrinogen-directed macrophage proinflammatory activity J Thromb Haemost (2022)

Elimination of fibrin polymer formation or crosslinking, but not fibrinogen deficiency, is protective against diet-induced obesity and associated pathologies J Thromb Haemost (2022)

Hypofibrinogenemia with preserved hemostasis and protection from thrombosis in mice with an Fga truncation mutation Blood (2022)

Suppression of fibrin(ogen)-driven pathologies in disease models through controlled knockdown by lipid nanoparticle delivery of siRNA Blood (2022)

Editorial of Special Column on Drug- and Chemical-Induced Liver Injury Acta Pharm Sin B (2021)

Factor XIII cross-links fibrin(ogen) independent of fibrin polymerization in experimental acute liver injury Blood (2021)

Plasmin-mediated cleavage of high-molecular-weight kininogen contributes to acetaminophen-induced acute liver failure Blood (2021)

Systemic inflammation and disorders of hemostasis in the AD-ACLF syndrome J Hepatol (2021)

Targeting von Willebrand factor in liver diseases: A novel therapeutic strategy? J Thromb Haemost (2021)

Von Willebrand factor exerts hepatoprotective effects in acute but not chronic cholestatic liver injury in mice Toxicology (2021)

A high-fat diet delays plasmin generation in a thrombomodulin-dependent manner in mice Blood (2020)

Hemostasis and Liver Regeneration Semin Thromb Hemost (2020)

Liver fibrosis is driven by protease-activated receptor-1 expressed by hepatic stellate cells in experimental chronic liver injury Res Pract Thromb Haemost (2020)

Von Willebrand factor delays liver repair after acetaminophen-induced acute liver injury in mice J Hepatol (2020)

Chronic liver injury drives non-traditional intrahepatic fibrin(ogen) crosslinking via tissue transglutaminase J Thromb Haemost (2019)

Coagulation parameters following equine herpesvirus type 1 infection in horses Equine Vet J (2019)

Dichotomous Role of Plasmin in Regulation of Macrophage Function after Acetaminophen Overdose Am J Pathol (2019)

Direct Amplification of Tissue Factor:Factor VIIa Procoagulant Activity by Bile Acids Drives Intrahepatic Coagulation Arterioscler Thromb Vasc Biol (2019)

Endothelial force awakens a mechanism of portal hypertension: It's a neutrophil extracellular trap! J Thromb Haemost (2019)

Illustrated State-of-the-Art Capsules of the ISTH 2019 Congress in Melbourne, Australia Res Pract Thromb Haemost (2019)

Intrahepatic fibrin(ogen) deposition drives liver regeneration after partial hepatectomy in mice and humans Blood (2019)

The multifaceted role of fibrinogen in tissue injury and inflammation Blood (2019)

Caspase Inhibition Reduces Hepatic Tissue Factor-Driven Coagulation In Vitro and In Vivo Toxicol Sci (2018)

Concepts and Controversies in Haemostasis and Thrombosis Associated with Liver Disease: Proceedings of the 7th International Coagulation in Liver Disease Conference Thromb Haemost (2018)

Plasminogen Activator Inhibitor-1 Reduces Tissue-Type Plasminogen Activator-Dependent Fibrinolysis and Intrahepatic Hemorrhage in Experimental Acetaminophen Overdose Am J Pathol (2018)

Platelets as Modulators of Liver Diseases Semin Thromb Hemost (2018)

Role of the blood coagulation cascade in hepatic fibrosis Am J Physiol Gastrointest Liver Physiol (2018)

Dose-dependent effects of alpha-naphthylisothiocyanate disconnect biliary fibrosis from hepatocellular necrosis J Biochem Mol Toxicol (2017)

Fibrin(ogen) drives repair after acetaminophen-induced liver injury via leukocyte α(M)β(2) integrin-dependent upregulation of Mmp12 J Hepatol (2017)

Lymphocytes contribute to biliary injury and fibrosis in experimental xenobiotic-induced cholestasis Toxicology (2017)

Plasminogen Activator Inhibitor-1 Is Critical in Alcohol-Enhanced Acute Lung Injury in Mice Am J Respir Cell Mol Biol (2017)

Targeting Phospholipase D4 Attenuates Kidney Fibrosis J Am Soc Nephrol (2017)

Thrombin promotes diet-induced obesity through fibrin-driven inflammation J Clin Invest (2017)

Trichloroethylene Exposure Reduces Liver Injury in a Mouse Model of Primary Biliary Cholangitis Toxicol Sci (2017)

Von Willebrand factor deficiency reduces liver fibrosis in mice Toxicol Appl Pharmacol (2017)

Evaluation of the chromogenic anti-factor IIa assay to assess dabigatran exposure in geriatric patients with atrial fibrillation in an outpatient setting Thromb J (2016)

Fibrin deposition following bile duct injury limits fibrosis through an αMβ2-dependent mechanism Blood (2016)

From the Cover: Coagulation-Driven Hepatic Fibrosis Requires Protease Activated Receptor-1 (PAR-1) in a Mouse Model of TCDD-Elicited Steatohepatitis Toxicol Sci (2016)

Hepatocyte tissue factor contributes to the hypercoagulable state in a mouse model of chronic liver injury J Hepatol (2016)

Inhibition of PAR-4 and P2Y12 receptor-mediated platelet activation produces distinct hepatic pathologies in experimental xenobiotic-induced cholestatic liver disease Toxicology (2016)

Mice with hepatocyte-specific FXR deficiency are resistant to spontaneous but susceptible to cholic acid-induced hepatocarcinogenesis Am J Physiol Gastrointest Liver Physiol (2016)

RNA Sequencing Identifies Novel Translational Biomarkers of Kidney Fibrosis J Am Soc Nephrol (2016)

Role of Fibrin(ogen) in Progression of Liver Disease: Guilt by Association? Semin Thromb Hemost (2016)

Role of hemostatic factors in hepatic injury and disease: animal models de-liver J Thromb Haemost (2016)

A balance between TFPI and thrombin-mediated platelet activation is required for murine embryonic development Blood (2015)

Coagulation-driven platelet activation reduces cholestatic liver injury and fibrosis in mice J Thromb Haemost (2015)

Platelets and protease-activated receptor-4 contribute to acetaminophen-induced liver injury in mice Blood (2015)

Circulating microparticle tissue factor activity is increased in patients with cirrhosis Hepatology (2014)

Coagulation in liver toxicity and disease: role of hepatocyte tissue factor Thromb Res (2014)

Fas-induced apoptosis increases hepatocyte tissue factor procoagulant activity in vitro and in vivo Toxicol Sci (2014)

H1-antihistamines exacerbate high-fat diet-induced hepatic steatosis in wild-type but not in apolipoprotein E knockout mice Am J Physiol Gastrointest Liver Physiol (2014)

Hepatic stellate cells orchestrate clearance of necrotic cells in a hypoxia-inducible factor-1α-dependent manner by modulating macrophage phenotype in mice J Immunol (2014)

Nrf2 promotes the development of fibrosis and tumorigenesis in mice with defective hepatic autophagy J Hepatol (2014)

The antifibrinolytic drug tranexamic acid reduces liver injury and fibrosis in a mouse model of chronic bile duct injury J Pharmacol Exp Ther (2014)

Thrombin inhibition with dabigatran protects against high-fat diet-induced fatty liver disease in mice J Pharmacol Exp Ther (2014)

Toxicogenomic analysis reveals profibrogenic effects of trichloroethylene in autoimmune-mediated cholangitis in mice Toxicol Sci (2014)

Hepatocyte tissue factor activates the coagulation cascade in mice Blood (2013)

IL-17A synergistically enhances bile acid-induced inflammation during obstructive cholestasis Am J Pathol (2013)

Keap1 knockdown increases markers of metabolic syndrome after long-term high fat diet feeding Free Radic Biol Med (2013)

Mechanisms of STAT3 activation in the liver of FXR knockout mice Am J Physiol Gastrointest Liver Physiol (2013)

PAR-1 contributes to the innate immune response during viral infection J Clin Invest (2013)

Small heterodimer partner overexpression partially protects against liver tumor development in farnesoid X receptor knockout mice Toxicol Appl Pharmacol (2013)

Early growth response factor-1 limits biliary fibrosis in a model of xenobiotic-induced cholestasis in mice Toxicol Sci (2012)

Fibrin(ogen)-independent role of plasminogen activators in acetaminophen-induced liver injury Am J Pathol (2012)

Lipopolysaccharide enhances transforming growth factor β1-induced platelet-derived growth factor-B expression in bile duct epithelial cells J Gastroenterol Hepatol (2012)

Monocyte tissue factor-dependent activation of coagulation in hypercholesterolemic mice and monkeys is inhibited by simvastatin J Clin Invest (2012)

Therapeutic administration of the direct thrombin inhibitor argatroban reduces hepatic inflammation in mice with established fatty liver disease Am J Pathol (2012)

Differential roles of unsaturated and saturated fatty acids on autophagy and apoptosis in hepatocytes J Pharmacol Exp Ther (2011)

Fibrinogen deficiency increases liver injury and early growth response-1 (Egr-1) expression in a model of chronic xenobiotic-induced cholestasis Am J Pathol (2011)

Protease-activated receptor 1 and hematopoietic cell tissue factor are required for hepatic steatosis in mice fed a Western diet Am J Pathol (2011)

Regulation of transforming growth factor-β1-dependent integrin β6 expression by p38 mitogen-activated protein kinase in bile duct epithelial cells J Pharmacol Exp Ther (2011)

Role of fibrinogen and protease-activated receptors in acute xenobiotic-induced cholestatic liver injury Toxicol Sci (2011)

Steatosis DeLIVERs high-sensitivity C-reactive protein Arterioscler Thromb Vasc Biol (2011)

The role of hypoxia-inducible factor-1α in acetaminophen hepatotoxicity J Pharmacol Exp Ther (2011)

Tissue factor contributes to neutrophil CD11b expression in alpha-naphthylisothiocyanate-treated mice Toxicol Appl Pharmacol (2011)

Comparison of TNFα to lipopolysaccharide as an inflammagen to characterize the idiosyncratic hepatotoxicity potential of drugs: Trovafloxacin as an example Int J Mol Sci (2010)

Effect of low-density lipoprotein apheresis on plasma levels of apolipoprotein e4 Am J Cardiol (2010)

Monocyte chemoattractant protein-1 deficiency does not affect steatosis or inflammation in livers of mice fed a methionine-choline-deficient diet Lab Invest (2010)

Protective and damaging effects of platelets in acute cholestatic liver injury revealed by depletion and inhibition strategies Toxicol Sci (2010)

The coagulation system contributes to alphaVbeta6 integrin expression and liver fibrosis induced by cholestasis Am J Pathol (2010)

Tissue factor-deficiency and protease activated receptor-1-deficiency reduce inflammation elicited by diet-induced steatohepatitis in mice Am J Pathol (2010)

Farnesoid X receptor deficiency induces nonalcoholic steatohepatitis in low-density lipoprotein receptor-knockout mice fed a high-fat diet J Pharmacol Exp Ther (2009)

Fibrin accumulation plays a critical role in the sensitization to lipopolysaccharide-induced liver injury caused by ethanol in mice Hepatology (2009)

Inflammatory stress and idiosyncratic hepatotoxicity: hints from animal models Pharmacol Rev (2009)

Rapamycin enhances LPS induction of tissue factor and tumor necrosis factor-alpha expression in macrophages by reducing IL-10 expression Mol Immunol (2009)

Tissue factor-dependent coagulation contributes to alpha-naphthylisothiocyanate-induced cholestatic liver injury in mice Am J Physiol Gastrointest Liver Physiol (2009)

Contribution of host-derived tissue factor to tumor neovascularization Arterioscler Thromb Vasc Biol (2008)

Genetic analysis of the role of the PI3K-Akt pathway in lipopolysaccharide-induced cytokine and tissue factor gene expression in monocytes/macrophages J Immunol (2008)

Insulin activation of the phosphatidylinositol 3-kinase/protein kinase B (Akt) pathway reduces lipopolysaccharide-induced inflammation in mice J Pharmacol Exp Ther (2008)

TLR4/CD14-mediated PI3K activation is an essential component of interferon-dependent VSV resistance in macrophages Mol Immunol (2008)

A novel class of antioxidants inhibit LPS induction of tissue factor by selective inhibition of the activation of ASK1 and MAP kinases Arterioscler Thromb Vasc Biol (2007)

COX-2 suppresses tissue factor expression via endocannabinoid-directed PPARdelta activation J Exp Med (2007)

Neutrophil interaction with the hemostatic system contributes to liver injury in rats cotreated with lipopolysaccharide and ranitidine J Pharmacol Exp Ther (2007)

Role of the coagulation system in acetaminophen-induced hepatotoxicity in mice Hepatology (2007)

The role of tumor necrosis factor alpha in lipopolysaccharide/ranitidine-induced inflammatory liver injury Toxicol Sci (2007)

The role of tumor-and host-related tissue factor pools in oncogene-driven tumor progression Thromb Res (2007)

Coagulation-dependent gene expression and liver injury in rats given lipopolysaccharide with ranitidine but not with famotidine J Pharmacol Exp Ther (2006)

Genetic susceptibility to thrombosis Curr Atheroscler Rep (2006)

Metabonomic evaluation of idiosyncrasy-like liver injury in rats cotreated with ranitidine and lipopolysaccharide Toxicol Appl Pharmacol (2006)

Metformin prevents alcohol-induced liver injury in the mouse: Critical role of plasminogen activator inhibitor-1 Gastroenterology (2006)

Metformin prevents endotoxin-induced liver injury after partial hepatectomy J Pharmacol Exp Ther (2006)

Microarray analysis of lipopolysaccharide potentiation of trovafloxacin-induced liver injury in rats suggests a role for proinflammatory chemokines and neutrophils J Pharmacol Exp Ther (2006)

Modest inflammation enhances diclofenac hepatotoxicity in rats: role of neutrophils and bacterial translocation J Pharmacol Exp Ther (2006)

Oncogenes, trousseau syndrome, and cancer-related changes in the coagulome of mice and humans Cancer Res (2006)

Unique gene expression and hepatocellular injury in the lipopolysaccharide-ranitidine drug idiosyncrasy rat model: comparison with famotidine Toxicol Sci (2006)

Coagulation-mediated hypoxia and neutrophil-dependent hepatic injury in rats given lipopolysaccharide and ranitidine J Pharmacol Exp Ther (2005)

Adverse hepatic drug reactions: inflammatory episodes as consequence and contributor Chem Biol Interact (2004)

Application of high-throughput Fourier-transform infrared spectroscopy in toxicology studies: contribution to a study on the development of an animal model for idiosyncratic toxicity Toxicol Lett (2004)

Gene expression analysis points to hemostasis in livers of rats cotreated with lipopolysaccharide and ranitidine Toxicol Sci (2004)

Role of hepatic fibrin in idiosyncrasy-like liver injury from lipopolysaccharide-ranitidine coexposure in rats Hepatology (2004)

Augmentation of aflatoxin B1 hepatotoxicity by endotoxin: involvement of endothelium and the coagulation system Toxicol Sci (2003)

Inflammation and drug idiosyncrasy--is there a connection? J Pharmacol Exp Ther (2003)

Ranitidine treatment during a modest inflammatory response precipitates idiosyncrasy-like liver injury in rats J Pharmacol Exp Ther (2003)

Antigen-presenting cell function during Plasmodium yoelii infection Infect Immun (2002)

Bacterial lipopolysaccharide exposure alters aflatoxin B(1) hepatotoxicity: benchmark dose analysis for markers of liver injury Toxicol Sci (2002)