Ling Huang , PhD

Publications

Abnormal exocrine--endocrine cell cross-talk promotes $β$-cell dysfunction and loss in MODY8 Nature Metabolism (2022)

Organoid Sensitivity Correlates with Therapeutic Response in Patients with Pancreatic Cancer Clinical Cancer Research (2022)

Personalized tumor vaccine for pancreatic cancer Cancer Immunology, Immunotherapy (2022)

Commitment and oncogene-induced plasticity of human stem cell-derived pancreatic acinar and ductal organoids Cell Stem Cell (2021)

Empirical identification and validation of tumor-targeting T cell receptors from circulation using autologous pancreatic tumor organoids Journal for immunotherapy of cancer (2021)

Genome-wide synthetic lethal screen unveils novel CAIX-NFS1/xCT axis as a targetable vulnerability in hypoxic solid tumors Science Advances (2021)

Discovery of New Targets to Control Metastasis in Pancreatic Cancer by Single-cell Transcriptomics Analysis of Circulating Tumor CellsSingle-cell RNA-seq to Uncover Metastatic Targets in PDAC Molecular Cancer Therapeutics (2020)

Discovery of a selective inhibitor of doublecortin like kinase 1 Nature chemical biology (2020)

PDX-derived organoids model in vivo drug response and secrete biomarkers JCI insight (2020)

Synthesis and Structure--Activity Relationships of DCLK1 Kinase Inhibitors Based on a 5, 11-Dihydro-6 H-benzo [e] pyrimido [5, 4-b][1, 4] diazepin-6-one Scaffold Journal of medicinal chemistry (2020)

Personalized RNA medicine for pancreatic cancer Clinical Cancer Research (2018)

Reversing the direction of galvanotaxis with controlled increases in boundary layer viscosity Physical biology (2018)

Prostate cancer--associated SPOP mutations confer resistance to BET inhibitors through stabilization of BRD4 Nature medicine (2017)

Ductal pancreatic cancer modeling and drug screening using human pluripotent stem cell--and patient-derived tumor organoids Nature medicine (2015)

Epidermal keratinocyte polarity and motility require Ca2+ influx through TRPV1 Journal of cell science (2013)

Rotational motion during three-dimensional morphogenesis of mammary epithelial acini relates to laminin matrix assembly Proceedings of the National Academy of Sciences (2013)

Polarity protein alterations in carcinoma: a focus on emerging roles for polarity regulators Current opinion in genetics & development (2010)

The involvement of Ca2+ and integrins in directional responses of zebrafish keratocytes to electric fields Journal of cellular physiology (2009)

Chick embryonic Schwann cells migrate anodally in small electrical fields Experimental neurology (2008)

A novel strategy to identify the regulatory DNA-organized cooperations among transcription factors FEBS letters (2006)