Jonathan Diedrich , PhD

Publications

Investigation of inherited noncoding genetic variation impacting the pharmacogenomics of childhood acute lymphoblastic leukemia treatment Nature Communications (2024)

Epigenomic mapping reveals distinct B cell acute lymphoblastic leukemia chromatin architectures and regulators Cell Genomics (2023)

Non-Toxicological Role of Aryl Hydrocarbon Receptor in Obesity-Associated Multiple Myeloma Cell Growth and Survival Cancers (2023)

Adipocyte-derived kynurenine stimulates malignant transformation of mammary epithelial cells through the aryl hydrocarbon receptor Biochemical Pharmacology (2023)

Epigenomic mapping in B-cell acute lymphoblastic leukemia identifies transcriptional regulators and noncoding variants promoting distinct chromatin architectures (2023)

Functional investigation of inherited noncoding genetic variation impacting the pharmacogenomics of childhood acute lymphoblastic leukemia treatment (2023)

Epigenomic profiling of glucocorticoid responses identifies cis-regulatory disruptions impacting steroid resistance in childhood acute lymphoblastic leukemia Leukemia (2022)

Epigenetic activation of the FLT3 gene by ZNF384 fusion confers a therapeutic susceptibility in acute lymphoblastic leukemia Nature Communications (2022)

Amino acid stress response genes promote L-asparaginase resistance in pediatric acute lymphoblastic leukemia Blood Advances (2022)

Profiling chromatin accessibility in pediatric acute lymphoblastic leukemia identifies subtype-specific chromatin landscapes and gene regulatory networks Leukemia (2021)

Genome-Wide Association Study of Susceptibility Loci for TCF3-PBX1 Acute Lymphoblastic Leukemia in Children JNCI: Journal of the National Cancer Institute (2021)

Integrative genomic analyses reveal mechanisms of glucocorticoid resistance in acute lymphoblastic leukemia Nature Cancer (2020)

Prostate Tumor Cell–Derived IL1β Induces an Inflammatory Phenotype in Bone Marrow Adipocytes and Reduces Sensitivity to Docetaxel via Lipolysis-Dependent Mechanisms Molecular Cancer Research (2019)

Adipocyte-activated oxidative and ER stress pathways promote tumor survival in bone via upregulation of Heme Oxygenase 1 and Survivin Scientific Reports (2018)

The Lipid Side of Bone Marrow Adipocytes: How Tumor Cells Adapt and Survive in Bone Current Osteoporosis Reports (2018)

Omentum and bone marrow: how adipocyte-rich organs create tumour microenvironments conducive for metastatic progression Obesity Reviews (2016)

Bone marrow adipocytes promote the Warburg phenotype in metastatic prostate tumorsviaHIF-1α activation Oncotarget (2016)

New 3D-Culture Approaches to Study Interactions of Bone Marrow Adipocytes with Metastatic Prostate Cancer Cells Frontiers in Endocrinology (2016)

Adipose tissue dysfunction and its effects on tumor metabolism Hormone Molecular Biology and Clinical Investigation (2015)

Bone-induced c-kit expression in prostate cancer: A driver of intraosseous tumor growth International Journal of Cancer (2015)